APOE Gene ε4 Allele Accelerates the Atrophy of the Inferior Temporal Lobe in Alzheimer's Disease
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بررسی پلی مورفیسم ژن APOE در بیماران ایرانی مبتلا به آلزایمر
Background: Alzheimer's disease is a multi-factorial disorder. The genes involved in Alzheimer's disease act as risk factors. The aim of this study was to investigate the APOE gene polymorphism in patients with Alzheimer's disease in Iran. Materials and Methods: In this analytical-descriptive study, 50 patients with Alzheimer's were investigated. Polymorphism of the APOE gene was investigated ...
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Temporal lobe epilepsy (TLE) is associated with some of the same neuropathological features as those reported for early stages of typical Alzheimer's disease (AD). The APOE ε4 allele is associated with a gene-dose-dependent increase in AD risk and in the severity of amyloid-β (Aβ) pathology. In a study published in the current BMC Medicine, Sue Griffin and colleagues studied markers of brain re...
متن کاملAPOE ε4 Is Associated with Disproportionate Progressive Hippocampal Atrophy in AD
OBJECTIVES To investigate whether APOE ε4 carriers have higher hippocampal atrophy rates than non-carriers in Alzheimer's disease (AD), mild cognitive impairment (MCI) and controls, and if so, whether higher hippocampal atrophy rates are still observed after adjusting for concurrent whole-brain atrophy rates. METHODS MRI scans from all available visits in ADNI (148 AD, 307 MCI, 167 controls) ...
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Comment. Possessing an APOE ε4 allele is the most important genetic risk factor yet identified for sporadic AD and also significantly lowers onset age. It is therefore striking that despite their young age at onset, only 2 of our 10 biparietal patients were ε4-positive. While we believe that a lack of association between biparietal AD (or posterior cortical atrophy AD) and APOE ε4 genotype has ...
متن کاملAPOE genotype and entorhinal cortex volume in non-demented community-dwelling adults in midlife and early old age.
The apolipoprotein E (APOE) ε4 allele is a risk factor for the neuropathological decline accompanying Alzheimer's disease (AD) while, conversely, the ε2 allele offers protection. One of the brain structures exhibiting the earliest changes associated with the disease is the entorhinal cortex. We therefore investigated the volumes of the entorhinal cortex and other structures in the medial tempor...
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تاریخ انتشار 2016